Afternoon Light Cyber Monday Furniture Deals All purchases are 10% off, with discounts that soar up to 25% off the more you spend. On top of producing new rugs-including a line of washable options that look exactly the same as regular ones-the brand also sells one-of-a-kind vintage rugs and some furniture, like this cozy ottoman. ![]() ![]() Wrapping up Monday evening, Revival’s tiered sale is one of the best places to find unique pieces for your home. Need a ridiculously comfy lounge chair, an upholstered bed frame, a modern nightstand, or a sofa you’ll never want to leave? It’s all on sale. While you might know it as a destination for high-quality bedding, it’s also home to some standout furniture, all of which has cool, coastal vibes. Our recommendations are based on first-hand experience of our commerce editors and writers, as well as verified reviews from shoppers.Įverything is 20% off at Parachute right now. Not only are we tracking shopping trends and staying abreast of what people around us are buying, but we purchase and extensively test products ourselves-including many of the items and brands in this story-so that we can share them with you. Best Christmas Decor Deal: Balsam Hill BH Balsam Fir With Burlap Base, ( $289) $259Īs Glamour's commerce team, we study the lay of the land when it comes to beauty, fashion, and home goods.Best Couch Deal: Anthropologie Meriwether Sofa, ($2,498) $1,749.Best Home Decor Deal: Ruggable Absida Rainbow Rug, ( $339) $254.Best Patio Furniture Deal: Ratcliff Adirondack Chair, ( $224) $170.Best Home Office Furniture Deal: Article Svelti Office Chair, ($89) $69.Best Living Room Furniture Deal: West Elm Lucia Wing Chair, ($799) $640.Best Bedroom Furniture Deal: Dalton Bed with 2 Table Sets ( $1,997) $1,899.Best Dining Room Furniture Deal: Best Choice Products Dining Set, ($350) $280.Best Cyber Monday Furniture Deals at a Glance Check out ASAP, as most of these Cyber Monday furniture sales will expire at midnight tonight. We’re adding live updates with the latest markdowns to this page, so be sure to check back frequently-you never know when your favorite new piece of furniture might go on super-sale.
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1/1/2024 0 Comments Ccleaner masterFeel free to use the brilliant filters to create a list of junk files that you wish to remove. Here, the powerful deep storage scanner tool will allow the app to look for all files, folders, and subfolders on your mobile devices. Optimize and clean your devicesĪnd for those of you who are interested, you can start to optimize and clean your devices with CCleaner whenever you want. Not to mention that the app itself is also extremely fast and efficient, as it only takes a small amount of local storage while using minimum RAM and CPU usage. Comfortably navigate between the different menus and features in the app to start improving your devices’ performances. ![]() Simply work with the clean UI to easily optimize your Android devices in just a few touches. To start with, Android users in CCleaner can quickly engage themselves in the simple and intuitive application with many useful features. 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Enjoy the free and unlocked app with our mods.Interesting themes for your cleaner app.Speed up your device by disabling unwanted apps. 1/1/2024 0 Comments Uctox 2When it was marketed, it gained widespread acceptance among physicians treating patients with arthritis and other conditions causing chronic or acute pain. Rofecoxib was approved by the FDA to treat osteoarthritis, rheumatoid arthritis, juvenile rheumatoid arthritis, acute pain conditions, migraine, and dysmenorrhea. The metabolic products are cis-dihydro and trans-dihydro derivatives of rofecoxib which are primarily excreted through urine. Rofecoxib crossed the placenta and blood–brain barrier, and took 1–3 hours to reach peak plasma concentration with an effective half-life (based on steady-state levels) around 17 hours. The therapeutic recommended dosages were 12.5, 25, and 50 mg with an approximate bioavailability of 93%. This was largely based on the VIGOR (Vioxx GI Outcomes Research) study, which compared the efficacy and adverse effect profiles of rofecoxib and naproxen. Īt the time of its withdrawal, rofecoxib was the only coxib approved in the United States with clinical evidence of its superior gastrointestinal adverse effect profile over conventional NSAIDs. Though the class of coxibs includes several agents, degrees of COX-2 selectivity vary among them, with celecoxib (Celebrex) being the least COX-2 selective, and rofecoxib (Vioxx), valdecoxib (Bextra), and etoricoxib (Arcoxia), being highly COX-2 selective. ![]() Rofecoxib is a selective COX-2 inhibitor, or "coxib". By creating "selective" NSAIDs that inhibit COX-2, but not COX-1, the same pain relief as traditional NSAIDs is offered, but with greatly reduced risk of fatal or debilitating peptic ulcers. COX-1 mediates the synthesis of prostaglandins responsible for protection of the stomach lining, while COX-2 mediates the synthesis of prostaglandins responsible for pain and inflammation. Ĭyclooxygenase (COX) has two well-studied isoforms, called COX-1 and COX-2. Traditional NSAIDs are avoided in this population due to their effects on platelet aggregation and risk of gastrointestinal ulcers, and high potency opioids are the current standard of care in treating HA. It is the largest cause of morbidity in patients with hemophilia and has no currently approved treatment options in the United States. HA is a degenerative joint disease caused by recurrent intra-articular bleeding. Tremeau announced that the FDA had granted an orphan designation for TRM-201 (rofecoxib) for the treatment of HA, and that they had received FDA feedback on their development plan. In November 2017, Massachusetts-based Tremeau Pharmaceuticals announced its plan to return rofecoxib (TRM-201) to market as a treatment for hemophilic arthropathy (HA). Based on data up to 2015, the FDA reasserted the likelihood of an increased risk of serious adverse CV events from COX-2–selective and nonselective NSAIDs, dependent on dose and duration. In 2005, the FDA issued a memorandum concluding that risks for serious cardiovascular (CV) events seem to be as great for nonselective NSAIDs as for COX-2–selective agents such as rofecoxib, according to long-term, controlled clinical trials. In the year before withdrawal, Merck had sales revenue of US$2.5 billion from Vioxx. Rofecoxib was one of the most widely used drugs ever to be withdrawn from the market. ![]() Merck withdrew the drug after disclosures that it withheld information about rofecoxib's risks from doctors and patients for over five years, allegedly resulting in between 88,000 and 140,000 cases of serious heart disease. In September 2004, Merck voluntarily withdrew rofecoxib from the market because of concerns about increased risk of heart attack and stroke associated with long-term, high-dosage use. Worldwide, over 80 million people were prescribed rofecoxib at some time. Rofecoxib gained widespread use among physicians treating patients with arthritis and other conditions causing chronic or acute pain. Rofecoxib was available by prescription in both tablets and as an oral suspension. ![]() Rofecoxib was approved in the US by the US Food and Drug Administration (FDA) in May 1999, and was marketed under the brand names Vioxx, Ceoxx, and Ceeoxx. ![]() to treat osteoarthritis, rheumatoid arthritis, juvenile rheumatoid arthritis, acute pain conditions, migraine, and dysmenorrhea. Rofecoxib is a COX-2-selective nonsteroidal anti-inflammatory drug ( NSAID). 1/1/2024 0 Comments Jumex pear nectarBe sure to stock them all to appeal to every guest. Everyone has a liquor they can’t drink anymore and one that serves as their go-to spirit. My years as a bartender taught me a lesson about what people are willing to drink. Every stocked home bar needs the usual well liquors: vodka, rum, whiskey, gin, and if you’re brave…tequila. Unflavored vodka isn’t sweet and goes well with just about any flavor. Sometimes a holiday inspires my cocktail recipes but other times it’s just the discovery of a flavored water, juice, or soda I haven’t tried yet. Boo-rific Blood Orange Cocktail is made even better by adding flavored vodka. You don’t have time to prep sangria fruit or brainstorm a punch bowl recipe. Some of you are busy this time of year balancing trick or treat night with the kids, classroom Halloween parties, and hey…maybe your own spirited affair just for adults. What’s great about these drinks is that they are super simple to make for party guests. Since I dress up myself and my house, of course I would dress up my Halloween themed cocktails. ![]() We won Best Costumed Couple last year as the beekeeper, queen bear, and baby bee (our dog) so the expectation for our costumes this year is intense. Of course, this year’s costume is super secret until Halloween night. ![]() Shout out to mom who set the bar high by sewing or helping me create my costumes from a young age. But you know what? The fang-tastic holiday will remain one of my favorite celebrations dating all the way back to my first clown costume in the kindergarten classroom party. I’ve shown up at costume parties as Amy Winehouse, a 20s flapper, zombie prom queen, scarecrow, 80s chick, and queen bee. Halloween is my excuse to dress up in costume. Give the Peaty Pera a try on one of these cold winter’s nights.Once every year I become someone I’m not. So we added a bit of thyme simple syrup (you can find a recipe for that in our Thyme to Shine cocktail) which really worked well with the flavors of pear and the amaro. Not wanting to just add sweetness, we decided to layer in a little more flavor. The drink was a little tart and we needed to bring the drink into balance with some added sweetness. We chose to use Amaro Lucano, an Italian amaro that has a nice blend of herbs and spices, with a great finish of warm baking spice and hint of bitterness.Ī splash of fresh squeezed lemon adds a bright citrus note that brings out the fruity notes of pear. Likewise, one way to bring some rich spicy complexity is to mix in a little amaro. If you want to learn more about Scottish Whisky, make sure to read our Scotch Regions guide!Ī good winter drink needs to have a nice layer of spice. This flavor is reminiscent of a roaring fire on the hearth which really works in a winter drink. We thought pairing it up with some pear nectar made perfect sense.The smoky flavors from the peat used to roast the malt imparts a deep dark flavor in the Scotch. Scotches have a rich malted flavor that works really well with sweet fruits like ripe pears and berries. Thyme Simple Syrup (instructions below!). ![]() Mixing Glass / Bar Spoon What Ingredients are Needed for the Peaty Pera? The homemade pear nectar was naturally sweet tart with a bright pear note and body that adds a decadent smoothness to a cocktail. We had made some homemade pear nectar for our Pink Pear cocktail so with that handy, it was only natural to use in the Peaty Pera. ![]() Since we have these great pears in season now, we figured a cocktail that combined two of our favorite winter flavors would be a real winner. This is why they start appearing in the dead of winter! Traditional varieties like the Anjou or the Bosc actually need to be exposed to temps below freezing for 4-6 weeks to fully ripen. So to fully allow the fruit to ripen, they need to be exposed to cold to prevent the pear from rotting. Pears, unlike apples, ripen from the inside out. Most people don’t realize that many of the great pear varieties like the Anjou or Bosc actually need to be chilled to ripen due to the unique way that pears ripen.Ĭoupe / Jigger Why are Pears Ripe in the Winter? We recently have been getting in some really great pears as the winter pears are finally fully ripe and ready to go. This post contains affiliate links for products that we think you as readers might find useful, and we make commission off of these! For more details about our affiliates, click our Disclosure and Contacts Page. When the weather turns cold, we turn to scotch cocktails! The Peaty Pera fits the bill, combining scotch whisky, amaro and pear to make a nice hearty winter cocktail! Scotch is a spirit that definitely packs a big bold flavor and a nice boozy punch. Winter is the time for hearty drinks full of flavor, and we are always thinking about ways we can make cocktails with big bold flavors. A Scotch, pear and Amaro cocktail! This Scotch Whisky pear Cocktail is great for winter. |
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